Back to Search Results

Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes.

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas. George Washington University Biostatistics Center, Washington, District of Columbia. Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio. Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah. Department of Obstetrics and Gynecology, Columbia University, New York, New York. Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island. Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama. Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Obstetrics and Gynecology, MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio. Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas. Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois. Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas. Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina.

American journal of perinatology. 2020;(5):475-482
Full text from:

Other resources

Abstract

OBJECTIVE The main purpose of this article is to evaluate whether identification and treatment of women with mild gestational diabetes mellitus (GDM) during pregnancy affects subsequent maternal body mass index (BMI), anthropometry, metabolic syndrome, and risk of diabetes. STUDY DESIGN This is a follow-up study of women who participated in a randomized controlled treatment trial for mild GDM. Women were enrolled between 5 and 10 years after their index pregnancy. Participants underwent blood pressure, height, weight, and anthropometric measurements by trained nursing personnel using a standardized approach. A nurse-assisted questionnaire regarding screening and treatment of diabetes or hypercholesterolemia, diet, and physical activity was completed. Laboratory evaluation included fasting serum glucose, fasting insulin, oral glucose tolerance test, and a lipid panel. Subsequent diabetes, metabolic syndrome, obesity, and adiposity in those diagnosed with mild GDM and randomized to nutritional counseling and medical therapy (treated) were compared with those who underwent routine pregnancy management (untreated). Multivariable analyses were performed adjusting for race/ethnicity and years between randomization and follow-up visit. RESULTS Four-hundred fifty-seven women with mild GDM during the index pregnancy were included in this analysis (243 treated; 214 untreated) and evaluated at a median 7 years after their index pregnancy. Baseline and follow-up characteristics were similar between treatment groups. Frequency of diabetes (9.2 vs. 8.5%, p =0.80), metabolic syndrome (32.2 vs. 34.3%, p =0.63), as well as adjusted mean values of homeostasis model assessment for insulin resistance (2.5 vs. 2.3, p =0.11) and BMI (29.4 vs. 29.1 kg/m2, p =0.67) were also not different. CONCLUSION Identification and treatment of women with mild GDM during pregnancy had no discernible impact on subsequent diabetes, metabolic syndrome, or obesity 7 years after delivery.

Methodological quality

Metadata